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Bone turnover markers have been widely utilised in the field of osteoporosis, particularly for the purpose of monitoring treatment adherence. However, a thorough understanding of the use and interpretation of biomarkers together with close cooperation between clinicians and laboratory medicine specialists is required for optimal use of these markers in clinical practice.
Notable contributions to the successful implementation of biomarkers in the field has resulted from the longstanding collaboration between the International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry (IFCC), which together have published seminal papers that have paved the way for a better utilisation of bone markers in clinical practice. To highlight the most important progress and offer insights into key topics in the field, Calcified Tissue International has now published a special edition of invited reviews authored by experts from the IOF, IFCC and the European Society for Clinical and Economical aspects of Osteoporosis and Musculoskeletal Diseases (ESCEO).
Professor Etienne Cavalier, editor of the special issue, states:
“We thank the leading authors who have contributed these authoritative reviews for this special issue. The reviews emphasise the significance of the analytical and preanalytical phases for optimal utilisation of current and emerging biomarkers of bone turnover and musculoskeletal diseases. We believe that these informative reviews will be useful not only for laboratory medicine specialists, but also for the clinicians who treat patients with various bone and musculoskeletal disorders on a daily basis.“
Read and download the articles:
- Editorial: Role of the Clinical Laboratory in the Assessment of Metabolic Musculoskeletal Diseases
E. Cavalier
https://link.springer.com/article/10.1007/s00223-022-01045-0
A Systematic Review of the Circadian Rhythm of Bone Markers in Blood - S. Seberg Diemar, S. Søgaard Dahl, A. Sode West, S. A. Simonsen, H. Klingenberg Iversen, N. Rye Jørgense https://link.springer.com/article/10.1007/s00223-022-00965-1
Practical Considerations for the Clinical Application of Bone Turnover Markers in Osteoporosis - S.D. Vasikaran, M. Miura, R. Pikner, H.P. Bhattoa, E. Cavalier on behalf of the IOF-IFCC Joint Committee on Bone Metabolism (C-BM)
https://link.springer.com/article/10.1007/s00223-021-00930-4 - Vitamin D Metabolites: Analytical Challenges and Clinical Relevance
N. Alonso, S. Zelzer, G. Eibinger & M. Herrmann
https://link.springer.com/article/10.1007/s00223-022-00961-5 - Role of Vitamin K in Bone and Muscle Metabolism
N. Alonso, A. Meinitzer, E. Fritz-Petrin, D. Enko & M. Herrmann
https://link.springer.com/article/10.1007/s00223-022-00955-3 - Biochemical Markers of Musculoskeletal Health and Aging to be Assessed in Clinical Trials of Drugs Aiming at the Treatment of Sarcopenia: Consensus Paper from an Expert Group Meeting Organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the Centre Académique de Recherche et d'Expérimentation en Santé (CARES SPRL), Under the Auspices of the World Health Organization Collaborating Center for the Epidemiology of Musculoskeletal Conditions and Aging.
A. Ladang, C. Beaudart, J-Y. Reginster, N. Al-Daghri, O. Bruyère, N. Burlet, M. Cesari, A. Cherubini, M. Coelho da Silva, C. Cooper, A. J. Cruz-Jentoft, F. Landi, A. Laslop, S. Maggi, A. Mobasheri, S. Ormarsdottir, R. Radermecker, M. Visser, M. Concepcion Prieto Yerro, R. Rizzoli, E. Cavalier
https://link.springer.com/article/10.1007/s00223-022-01054-z
Bone Turnover Markers in Children: From Laboratory Challenges to Clinical Interpretation - A. Ladang, F. Rauch, E. Delvin, E. Cavalier
https://link.springer.com/article/10.1007/s00223-022-00964-2
Alkaline Phosphatases: Biochemistry, Functions, and Measurement - K. Makris, C. Mousa E, E. Cavalier
https://link.springer.com/article/10.1007/s00223-022-01048-x
New Emerging Biomarkers for Bone Disease: Sclerostin and Dickkopf-1(DKK1) - A. Sepinci Dincel & Niklas Rye Jørgensen on behalf of the IOF-IFCC Joint Committee on Bone Metabolism (C-BM)
https://link.springer.com/article/10.1007/s00223-022-01020-9 - The Measurement and Interpretation of Fibroblast Growth Factor 23 (FGF23) Concentrations
A.C. Heijboer & E. Cavalier
https://link.springer.com/article/10.1007/s00223-022-00987-9
Micro-RNA: A Future Approach to Personalized Diagnosis of Bone Diseases - G. Lombardi & E. Delvin
https://link.springer.com/article/10.1007/s00223-022-00959-z
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About Calcified Tissue International & Musculoskeletal Research
Calcified Tissue International & Musculoskeletal Research is a peer-reviewed journal which publishes original preclinical, translational and clinical research, and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms, as well as clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions. https://www.springer.com/journal/223
Editors in Chief: Stuart Ralston and René Rizzoli; Musculoskeletal Research Section Editor: Roger Fielding
About IOF
The International Osteoporosis Foundation (IOF) is the world's largest nongovernmental organization dedicated to the prevention, diagnosis and treatment of osteoporosis and related musculoskeletal diseases. IOF members, including committees of scientific researchers as well as more than 310 patient, medical and research organizations, work together to make fracture prevention and healthy mobility a worldwide heath care priority. https://www.osteoporosis.foundation @iofbonehealth
About IFCC
The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) is a worldwide, non-political organization for clinical chemistry and laboratory medicine. As such it has a range of roles that include (1) global standard setting in collaboration with other international organizations, (2) supporting its members through scientific and educational endeavour, and (3) providing a series of congresses, conferences and focussed meetings in order for laboratory medicine specialists to meet and present original findings and best practice. https://www.ifcc.org/
About ESCEO
The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) is a non-profit organization, dedicated to a close interaction between clinical scientists dealing with rheumatic disorders, pharmaceutical industry developing new compounds in this field, regulators responsible for the registration of such drugs and health policymakers, to integrate the management of osteoporosis and osteoarthritis within the comprehensive perspective of health resources utilization. The objective of ESCEO is to provide practitioners with the latest clinical and economic information, allowing them to organize their daily practice, from an evidence-based medicine perspective, with a cost-conscious perception. https://www.esceo.org/